RESUMO Objetivo Avaliar o efeito da Justicia acuminatissima , Sara Tudo do Amazonas, na função renal, na hemodinâmica renal, no perfil oxidativo e na histologia renal em ratos com injúria renal aguda isquêmica. Método Ensaio pré-clÃnico com ratos Wistar, adultos, machos (250-350 g), distribuÃ...
RESUMO Objetivo Avaliar o efeito do antibiótico gentamicina em modelo experimental na presença de Diabetes Mellitus por meio da função renal e perfil oxidativo. Método Ratos Wistar, adultos, machos, foram distribuÃdos nos grupos: Citrato; Gentamicina (Genta), (gentamicina 100 mg/kg de peso corp...
ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdomin...
AcetilcisteÃna/farmacologÃa,
AcetilcisteÃna/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/prevención & control,
Antioxidantes/farmacologÃa,
Antioxidantes/uso terapéutico,
Brasil,
Ciego/efectos de los fármacos,
Ciego/lesiones,
Diosmina/farmacologÃa,
Diosmina/uso terapéutico,
Modelos Animales de Enfermedad,
Hesperidina/farmacologÃa,
Hesperidina/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Sepsis/complicaciones,
Sepsis/tratamiento farmacológico
ABSTRACT Objective: to evaluate the nursing workload in intensive care patients with acute kidney injury (AKI). Method: A quantitative study, conducted in an intensive care unit, from April to August of 2015. The Nursing Activities Score (NAS) and Kidney Disease Improving Global Outcomes (KDIGO) were u...
RESUMO Objetivo Avaliar ação renoprotetora dos flavonoides diosmina e hesperidina na prevenção da nefrotoxicidade da anfotericina B em modelo experimental com ratos. Método Ratos Wistar, adultos, machos foram distribuÃdos nos seguintes grupos: Salina; diosmina hesperidina (animais receberam 50 mg/k...
Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Phy...
The aim of the study was to characterize the cell damage mechanisms involved in the pathophysiology of cytotoxicity of polymyxin B in proximal tubular cells (LLC - PK1) and discuss about the nurses interventions to identify at risk patients and consider prevention or treatment of nephrotoxicity acute kid...
OBJECTIVE: Evaluating the renoprotective effect of Echinodorus macrophyllus in acute kidney injury induced by cyclophosphamide in rats. METHODS: Experimental research with Wistar rats, male adults, distributed into groups, namely: Control - administration of 1.5 ml sodium chloride 0.9% intraperitoneally;...
Experimental animal models offer possibilities of physiology knowledge, pathogenesis of disease and action of drugs that are directly related to quality nursing care. This integrative review describes the current state of the instrumental and ethical aspects of experimental research with animal models, i...
Objetivos: Verificar a proteção funcional da heme-oxigenase (HO-1), por meio do uso do seu indutor (Hemin) e seu inibidor quÃmico (protoporfirina de zinco-ZnPP) na lesão renal aguda isquêmica e tóxica pela Polimixina B (PmxB) em ratos. Material: Foram utilizados ratos Wistar, adultos e machos divid...
